Genotypic characterization of HIV variants from PBMCs and spermatozoa
نویسندگان
چکیده
Background Several studies have shown that detectable levels of HIV are observed in semen in spite of undetectable viral load in blood following antiretroviral therapy (ART). Also, different HIV variants have been detected in blood and semen of the same individual, suggesting that drugs may not be uniformly effective to control the viral load and infectivity in different tissues and secretions, which in turn may affect sexual transmission of HIV. Hence, genotypic characterization of HIV variants in PBMCs and sperm of the same individual may provide information about the association of these variants with sexual transmission of HIV.
منابع مشابه
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عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2014